World’s Oldest Host-Associated Microbial DNA Obtained from Ancient Mammoth Remains

Guinet et al. reconstructed partial genomes of Erysipelothrix from the oldest mammoth sample, representing the oldest authenticated host-associated microbial DNA to date. Image credit: Guinet et al., doi: 10.1016/j.cell.2025.08.003.

In a new study, scientists analyzed ancient microbial DNA from 483 mammoth remains spanning over 1 million years, including 440 newly-sequenced and unpublished samples from a 1.1-million-year-old steppe mammoth.

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