A new study led by researchers at the University of Cambridge, in collaboration with international institutions, has uncovered a key mechanism in how DNA behaves as it passes through nanoscale pores—a process central to many biological functions and emerging DNA sensing technologies. The study sheds new light on a structural “hidden player,” plectonemes, long missed by researchers, with the potential to reshape biosensing and genomic technologies.
Uncovering hidden DNA structures during nanopore sensing: Plectonemes take center stage
